UVA School of Medicine

Research Computing

Enabling scientific breakthroughs at scale with advanced computing


  • LOLAweb

    From his lab in the Center for Public Health Genomics at UVa, Nathan Sheffield seeks to develop a deeper understanding of functional genomics. Dr. Sheffield and his collaborators study epigenetic mechanisms, including DNA methylation, which can involve analyzing enrichment of genomic region set data. By identifying patterns of enriched genomic regions, one can differentiate between normal and diseased gene regulation. Dr. Sheffield builds on this research focus as well as a history of open-source software development with the publication of LOLAweb: A containerized web server for interactive genomic locus overlap enrichment analysis as part of a special web server issue of Nucleic Acids Research.